Gut Microbiota Modulate the Efficacy of Angiotensin‐converting Enzyme Inhibitor Captopril

P23: The Effects of Captopril, as Angiotensin Converting Enzyme Inhibitor, on LPS-Induced Systemic Inflammation

It has been shown that the renin-angiotensin system (RAS) plays key roles in the inflammation process. Imbalance in the oxidant-antioxidant system is one of the major causes of inflammation. In the present study, the effects of captopril on total and differential WBC, oxidative stress in systemic inflammation produced by lipopolysaccharide (LPS) were investigated. The rats were divided to: cont...

Exercise can help modulate human gut microbiota

McFadzean, Robert, "Exercise can help modulate human gut microbiota" (2014). Undergraduate Honors Theses. Paper 155. Abstract Moderate exercise has been shown to be beneficial to health in many ways, including reducing stress, building a stronger immune system and increasing cardiovascular health. Recent studies in the human gut microbiome have demonstrated benefits of certain microorganisms in...

Impact of the Gut Microbiota on Vaccine Responses

Non-responsiveness or poor responsiveness to vaccines are challenging issues in vaccine development, and efforts have been made to find out the potential reasons for these conditions. Intestinal microbiome plays a key role in regulating and development of immune system and the composition and diversity of microbiota in different individuals on the one hand, and the imbalance of intestinal micro...

Gut Microbiota and Neuropsychiatric Disorders

Clinical use of an orally acting converting enzyme inhibitor: captopril.

An orally Retire inhibitor of the angtotensin conrerting enzyme, SQ 14,225 or captopril, was administered to 14 normal rolnnteers to evaluate its efficacy in inhibiting the pressor response to exogenous angiotensin I. The degree of blockade was dose-related op to 10 mg of captopril. Increasing the dose further merely prolonged the duration of the blockade. Subsequently, 39 patients with various...